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#covid

336 posts214 participants23 posts today
Public
Tom Kindlon

US research

Dysautonomia in long COVID is prevalent and could explain the frequency of symptoms

medrxiv.org/content/10.1101/20

#dysautonomia @dysautonomia #pots @pots @longcovid
#LongCovid #PwLC #PostCovidSyndrome #LC #PASC #postcovid
#CovidBrain
@covid19 #COVIDー19 #COVID19 #COVID #COVID_19 #SARSCoV2

medRxiv · Dysautonomia in long COVID is prevalent and could explain the frequency of symptomsBackground Long COVID presents with a variety of symptoms. Some of those symptoms could be related to autonomic dysfunction. Our aim is to evaluate the prevalence of autonomic dysfunction in long COVID patients. Methods We conducted a cross-sectional study and included all consecutive patients enrolled in several clinical research studies. We performed the following autonomic dysfunction markers: heart rate variability, heart rate, systolic and diastolic blood pressure changes during NASA lean test, cardiopulmonary exercise testing and a COMPASS-31 scale. We used linear regression to calculate the contribution of each dysautonomia measure on symptom burden as measured by the modified COVID-19 Yorkshire scale. Results We included 100 patients for this study. Our sample had a mean age of 56+/-11 years, included 53% minorities and 32% were women. Dysautonomia as defined by an abnormal COMPASS-31 was seen in 82%; 95% 72-89 while cardiovascular resting dysautonomia as represented by an abnormal heart rate variability was seen in 60%; 95% 48-70 of the population, orthostatic hypotension in 12% and POTS in 10%. In our adjusted analysis, we found that the beta coefficient for the COMPASS-31 score (0.37) was significant on changes in a self-reported long COVID symptom burden. The orthostatic intolerance and gastrointestinal domains of the COMPASS-31 was associated the highest long COVID symptom burden. Conclusion Dysautonomia is common in long COVID patients and contributes to the overall symptoms seen in long COVID. Identifying dysautonomia has important diagnostic and therapeutic implications. ### Competing Interest Statement The authors have declared no competing interest. ### Clinical Trial NA ### Funding Statement Yes ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: All studies were approved by the research ethics committees at the Miami VAHS and NOVA Southeastern University and all participants signed informed consent prior to participation. Miami VA is the IRB of record I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes Data cannot be shared publicly because it is owned but the Veterans Affairs.
Public
Tom Kindlon

New UK research:

Long-term effects of #SARSCoV2 infection on blood vessels and blood pressure

journals.lww.com/jhypertension

"Persistent vascular dysfunction and BP increase post-COVID-19 underscore the need for further studies on the long-term risk of hypertension & cardiovascular disease”

@longcovid
#LongCovid #PwLC #LC #PASC #postcovid
@covid19 #COVIDー19 #COVID19 #COVID #COVID_19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver

Graphical abstract
Public
If the oceans die, we die....

The murderer criminal Donald Trump belongs in prison.Every time I speak to one of his supporters they pass the blame.
I point out that while he was not responsible for Covid, he was responsible for protecting the country and people. Hundreds of thousands died. On his watch. Even if he denies it. If he let or could have prevented only 1 he bares some responsibility as the leader of the country.
But he rather play golf. Never forget.
Now his actions will result more deaths.
#covid #deaths #ușă

Public
(((Cindy Weinstein)))

As the #NIH slashes funding for research into #Alzheimer's, #cancer, #COVID & #diseases that inflict pain & suffering, I'm heartbroken & furious. #Early-onset Alzheimer's took my father away from me &, more importantly, himself. Why would anyone in their right mind (right, the mind of the #fascist is almost incomprehensible) do such a thing? If nothing else, a selfish viewpt. says this is idiocy. These cuts are meant to bring us to our knees. Let's resist (& sue them into oblivion).

#Deathcult
Public
Bích-Mây Nguyễn :verified:

"Just one of 13 Republicans on the Senate Medical Affairs Committee voted for Dr. Edward Simmer ‘s nomination to lead the new Department of Public Health — in contrast to the Republican-dominated Senate’s overwhelming endorsement of Simmer in 2021 as head of the state’s old public health and environmental agency."

apnews.com/article/south-carol

#PublicHealth#SouthCarolina#covid
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